Biohacking APOE4 Brain Longevity
My living blueprint for fighting back against genetic risk and brain aging
I carry two copies of the APOE4 gene – the strongest known genetic risk factor for late-onset Alzheimer’s disease. Yet at 73, I remain cognitively healthy, fiercely independent, and deeply committed to staying that way.
What makes this site different is that it combines science with lived experience.
I am not simply sharing promising Alzheimer’s prevention strategies – I am actively implementing them, measuring them, refining them, and documenting the results in real time as an APOE4/4 carrier now in my seventies.
This blueprint reflects the path I have built over the past eight years: what I track, what I test, what I change, what I keep, what I abandon, and why.
My prevention strategy is largely informed by Dr. Dale Bredesen’s PreCODE framework, combined with ongoing scientific research, personal biomarker data, and real-world application. It has also been shaped by the work of leading experts in brain health and Alzheimer’s prevention, including Dr. Richard Isaacson, Dr. David Perlmutter, Dr. Hussein Yassine, Dr. Dayan Goodenowe, Tal Nuriel and others.
Here, I share:
- The routines I actually follow
- The labs I track and how I interpret them
- The supplements, therapies, and tools I use
- The reasoning behind major decisions and course corrections
Not as medical advice, but as a working blueprint you can learn from, adapt, and discuss with your clinician.
Why This Matters (to me)
I refuse to accept a future where Alzheimer’s disease takes my memory – the very essence of who I am.
If I lose awareness of where I come from, where I’m going, and who the people I love are, then for me, life loses its meaning. Others may feel differently, and I respect that.
I also have a personal theory: many of the diseases that plague us in the final decades of life become far less likely when we succeed in extending our healthspan and vitality span. The longer we remain physically strong, metabolically healthy, cognitively engaged, and connected to purpose, the less opportunity disease has to gain a foothold.
My path is clear: I will do everything within my control to preserve my cognition, independence, and dignity. This site is the record of that journey – an evolving blueprint built from science, experience, persistence, and hope.
What you’ll find here
A clear and concise framework built from lived experience
This site organizes what I’m doing, what I’m measuring, and what I’m learning into a 9-module blueprint – so you can explore ideas, ask better questions, and build your own plan with your clinician.
The Blueprint I implemented
My prevention blueprint is organized into practical steps: where to begin, lifestyle, sleep, exercise, nutrition, and ongoing follow-up. Along the way, I share what a typical day looks like for me and how I’ve learned to put these strategies into practice without turning them into a full-time job—or letting APOE4 define my life.
Labs and biomarkers I track
A running list of labs I monitor and why they matter. I share my own comprehensive downloadable spreadsheet to help you track your own markers and progress.
Educational resources (not medical advice)
Curated notes, on supplements, off-label drugs, peptides and more – shared for education and conversation with your own care team. I also have a video library included, as well as links to clinical trials of interest regarding Alzheimer’s and APOE4, in particular.
Resources
Module Examples
My Blueprint reflects how I actually work day to day – planning labs, tracking supplements, and sanity-checking the numbers that matter..
My Labs I Targets Tracked
Biomarkers, target ranges to discuss, and how I track and organize them personally
My Supplement Stack
What I take, what I’ve stopped, and the notes I keep on dose, timing, and tolerability.
Calculators
Simple calculators for common biomarker ratios and health metrics – built for quick checks.
My Therapeutic Tools/Devices
Tools for measuring, improving, and maintaining health and resilience, sleep and relaxation.
My Food Choices
The whole-food, low carb rotating menus I reach for and all without giving up enjoyment!
My Prevention BluePrint
Overwhelmed by APOE4?
Important context
How to use this site safely and effectively
I share what I’m doing and learning as an APOE4/4 carrier. Use this as a starting point for research and discussion – not a substitute for medical care.